A Comparison of Lymphocytes from Adult Peripheral Blood versus Umbilical Cord Blood

With the rapid advancement of cell therapies, there is a demand for cellular starting materials that are robust, reproducible, well-characterized, and clinically relevant. Many adoptive cell therapies are based on lymphocytes and hematopoietic stem cells. Whether it’s allogeneic CAR-T or hematopoietic stem cell transplantation (HSCT), clinical development and commercial scale up and scale out require a high quantity of high quality cells […]

The Story of T Lymphocytes

Some say that CAR-T (Chimeric Antigen Receptor T cell) revolutionized cell therapy and transformed the manufacturing technologies of the industry. Following the approval and success of the CD19 CAR-T, many more tumor-specific molecules are being explored and targeted by CAR technology. The most exciting developments are allogeneic CAR-T which may be easier to manufacture in […]

A Brief Introduction to Immunology

Breakthroughs in immunotherapy, such as chimeric antigen receptor T cell (CAR-T) therapy  and checkpoint inhibition antibodies, have led to a rejuvenated interest in the human immune system. Insights from basic immunology research drive approaches and innovations in the exploding immunotherapy field (Figure 1). Studies of tumor-infiltrating lymphocytes helped shed light on the complex tumor microenvironment and the mechanisms of […]